MxA protein interacts with negatively charged round liposomes and transforms them into long helical tubes, displaying a characteristic T- shape structure at the lipid outer surface. MxA is a key component of the innate antiviral response. MxA tubes might act as a stable storage form, from which antivirally active monomers are released.
MxA forms ER-associated homooligomers. Upon infection, MxA monomers are released. MxA monomers form copolymers with the viral NPs and associate them to the ER. Misslocation of the NPs to the ER leads to viral inhibition