Scheme depicting the mechanism of NP internalization. Hydrophilic NPs adsorb to the lipid are wrapped and finally internalized into the fluid liposomes, thereby forming supported lipid bilayer (SLB) NPs (the inset depicts the process of invagination)
A model depicting the function of dynamin in fission (left), and s-Mgm1 in fusion (right). Both dynamin and Mgm1 shape membranes in vivo and in vitro. Dynamin dimers assemble into a helical collar, which upon GTPase activity constrict the underlying membrane to mediate fission. We propose that s-Mgm1 forms a homo-oligomeric complex in trans to create protein bridges and ordered lattices that tether opposing membranes to support mitochondrial inner membrane cristae structures, and to also undergo a GTP-induced transition to promote fusion.